Vascular Complications of Fungal Meningitis Attributed to Injections of Contaminated Methylprednisolone Acetate

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Vascular complications of fungal meningitis attributed to injections of contaminated methylprednisolone acetate.

IMPORTANCE Fungal meningitis due to injections of contaminated methylprednisolone acetate can present with vascular sequelae in immunocompetent individuals. This is particularly germane to neurologists because better recognition of the clinical characteristics of patients with fungal meningitis and ischemic stroke will provide more timely and efficient care. OBSERVATIONS In a case series, 3 p...

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Fungal infections associated with contaminated methylprednisolone injections.

BACKGROUND Fungal infections are rare complications of injections for treatment of chronic pain. In September 2012, we initiated an investigation into fungal infections associated with injections of preservative-free methylprednisolone acetate that was purchased from a single compounding pharmacy. METHODS Three lots of methylprednisolone acetate were recalled by the pharmacy; examination of u...

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Fungal meningitis due to contaminated epidural steroid injections.

In the fall of 2012, as we finalized this issue of , an unprecedented outbreak of fungal meningitis occurred that was caused by contaminated preservative-free methylprednisolone acetate solution from the New England Compounding Center used in epidural steroid injections in thousands of patients. The predominant pathogen was found to be Exserohilum rostratum (a black mold). Aspergillus fumigatus...

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Spinal and Paraspinal Fungal Infections Associated With Contaminated Methylprednisolone Injections

BACKGROUND A nationwide outbreak of fungal infections was traced to injection of Exserohilum-contaminated methylprednisolone. We describe our experience with patients who developed spinal or paraspinal infection after injection of contaminated methylprednisolone. METHODS Data were assembled from the Michigan Department of Community Health, electronic medical records, and magnetic resonance im...

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Exserohilum rostratum fungal meningitis associated with methylprednisolone injections.

In October 2012, the CDC reported an outbreak of fungal meningitis associated with methylprednisolone injections [1]. Although the index case had Aspergillus fumigatus meningitis [2], subsequent reports indicated that the majority of affected patients had meningitis caused by Exserohilum rostratum, an extremely rare cause of human fungal disease [1,3,4]. The outbreak is presumably the result of...

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ژورنال

عنوان ژورنال: JAMA Neurology

سال: 2013

ISSN: 2168-6149

DOI: 10.1001/jamaneurol.2013.3586